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PREGNANCY-ASSOCIATED PLASMA PROTEIN-A
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DeCS
Descriptor
English
:
Pregnancy-Associated Plasma Protein-A
Descriptor
Spanish
:
Proteína Plasmática A Asociada al Embarazo
Descriptor
Portuguese
:
Proteína Plasmática A Associada à Gravidez
Synonyms
English
:
PAPP-A
Tree Number:
D08.811.277.656.300.480.632
D08.811.277.656.675.374.632
D12.776.780.700
Definition
English
:
A product of the
PLACENTA
, and
DECIDUA
, secreted into the maternal circulation during
PREGNANCY
. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human
FIBROBLASTS
, ovarian
FOLLICULAR FLUID
, and
GRANULOSA CELLS
. The enzyme is a heterotetramer of about 500-kDa.
History Note
English
:
2004 (1996)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
11686
Unique Identifier:
D011266
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS